91³Ô¹ÏÍø

>

NanoExchange | Week 6

Week 6 NanoExchange, Speakers Vikash Khokhar and Mia Woodruff

Join us for Week 2 of the NanoExchange Summer Series. Each session brings together graduate researchers to share work-in-progress, explore new ideas, and engage in open discussion across disciplines.

This summer’s NanoExchange is chaired by IMS Graduate Students Jack Loken and Jojo Pearson.

Date: Thursday, July 23, 2026
Coffee and Snacks: 10:00 to 10:30 AM
NanoExchange Sessions: 10:30 to 11:30 AM
Location: 202 Light Hall


Vikash Khokhar |±«²Ô¾±±¹±ð°ù²õ²¹±ôÌýEffect ofÌýA³¾³¾´Ç²Ô¾±²¹ÌýPressure onÌýSynthesis ofÌýC´Ç±ô±ô´Ç¾±»å²¹±ôÌýM±ð³Ù²¹±ôÌýNitrides inÌýM´Ç±ô³Ù±ð²ÔÌýSalts
Metal nitridesÌýrepresentÌýa large class of materials with extensive applications in optoelectronics, energy, and healthcare technologies. For example,ÌýGaNÌýand related nitride semiconductors are key materials for solid-state lighting and high-power electronics; TiN and other early transition metal nitrides (TMNs) are widely used in wear-resistant alloys, tool coatings,ÌýcatalystsÌýand medical implants. Strong metal–nitrogen bonds grant nitrides structural rigidity as well as chemical and thermal stability. However, the covalency of metal-nitrogen bondsÌýnecessitatesÌýhigh temperaturesÌýto synthesize crystalline metal nitrides. The solution synthesis of colloidal nitride nanocrystals (NCs) is rare and particularly challenging because commonly used solvents and surfactants decompose at temperatures far below thoseÌýrequiredÌýfor crystallization of most metal nitrides. Here we report a general approach to solution synthesis of colloidal metal nitride NCs by reacting metal halides and ammonia dissolved in molten inorganic salts at elevatedÌýMaybpressures. Successful syntheses of colloidal TiN, VN,ÌýGaN,ÌýNbN, Mo2N, Ta3N5, W2N, as well as ternary Ti1-xVxN NCs, areÌýdemonstrated. These NCs expand the scope of solution-processable technologically important materials. We also explored, using DFT and AIMD, how molten salt and dissolved ammonia stabilize colloidal NCs.Ìý

Mia Woodruff | Albumin-Hitchhiking Nanobody-Antigen Fusions for Inducing Antigen-Specific Immune ToleranceÌý
Autoimmune diseases (ADs) are a diverse group of disorders characterized by a dysregulated immune response, causing inflammation and tissue damage. Due to their heterogeneity, it is difficult to characterize the global prevalence rates of all ADs, but current research estimates that around one in ten people are affected. This rate is expected to increase, with certain diseases such as Type 1 diabetes (T1D) and Multiple Sclerosis (MS)ÌýobservingÌýrobust increases in incidence rates over the past decade. Current treatments for ADs widely suppress T-cell and B-cell populations as well as their egress into the CNS, such as anti-CD20 antibodies and S1P inhibitors. With the chronic administration of these medications, patients typically suffer from immunosuppression and an increased infection risk. Here, we have developed albumin-based carriers for antigen-specific immunotherapy that can selectively tolerize autoreactive lymphocytes and minimize immunosuppression. Albumin has many tolerogenic properties due to its role inÌýmaintainingÌýosmotic pressure in the blood; namely, it is highly expressed, non-inflammatory, and has a long half-life. We hypothesize that attaching antigens to albumin will extend their circulation time, thereby increasing exposure to antigen-presenting cells in a non-inflammatory context, creating the ideal environment for inducing immune tolerance. Our team has designed tolerizing