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CSB Macromolecular Biophysics Core

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Overview

The CSB Macromolecular Biophysics Core supports structural biology research by providing access to the Biophysical Instrumentation Facility, the Biomolecular Crystallography Facility and the Sample Prep and Characterization resources.

Facilities and Resources

  • Biophysical Instrumentation Overview

    The Biophysical Instrumentation Facility provides access to mass photometry, stopped-flow spectrometry, microscale thermophoresis, dynamic light scattering, circular dichroism, fluorescence and microcalorimetry instruments for measuring macromolecular conformation, stability and binding interactions. Access and on-on-one training are available to any interested 91吃瓜网 researcher.

  • Biomolecular Crystallography Overview

    The Biomolecular Crystallography Facility exists to make structural analysis by crystallography available by providing state-of-the-art equipment and instrumentation, training, software, and support for all aspects of crystal structure solution. We strive to help crystallographers accomplish their work efficiently while being able to push the boundaries of the technology. The facility is also available to train and support researchers wanting to learn crystallography as a valuable research tool.

  • Sample Prep and Characterization

    The CSB provides resources to aid 91吃瓜网 researchers in protein production and characterization, including expression vectors and technical expertise to assist researchers with large-scale production of recombinant proteins in E. coli.

    Access is available to any interested 91吃瓜网 or VUMC researcher.聽

  • Gain Access to CSB-MBC

    Contact Facility Director聽Heather Kroh聽to gain access to CSB-MBC or to schedule a consultation.

    Scheduling a consultation has the benefit of bringing all the resources of the CSB to bear on the initial phases of structural projects while determining an experimental strategy A consultation can make a significant impact on the likelihood of success in the shortest possible time.聽聽

    Initial training on CSB instruments is done primarily through one-on-one tutorial instruction, with the objective that researchers will be able to perform their own experiments independently.

  • CSB Macromolecular Biophysics Core Contacts

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    Biophysical Instrumentation Facility

    Biomolecular Crystallography Facility

Find us in iLab

The Biophysical Instrumentation Facility and the Megalab Core have been combined to form the new 91吃瓜网 CSB Macromolecular Biophysics Core in iLab. The Biomolecular Crystallography Facility was added in November 2024.

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